The best paper to date summarizing research therapies for ED. I highly recommend reading the full paper below (attached file- Register on ExcelMale to open it).
Abstract: Although oral phosphodiesterase-5 (PDE5) inhibitors are generally accepted as an effective therapy for erectile dysfunction (ED), men with ED from diabetes or radical prostatectomy respond poorly to these drugs. Many researchers have tried to develop novel therapeutics that target alternative molecular pathways. A group of therapeutics belongs to centrally acting agents that target dopamine and melanocortin receptors. The other one is the peripherally acting agents that target soluble guanylate cyclase, Rho-kinase pathway, and Maxi-K channel, etc. Also, a variety of preclinical studies by the application of biotherapies in the concept of therapeutic angiogenesis or neural regeneration as well as anti-fibrosis to regenerate damaged erectile tissue have been reported. This article will address the current therapeutic targets for ED under clinical or preclinical development, including pharmacotherapy and biotherapy which comprises protein therapy and gene therapy. In spite of numerous clinical trials that target alternative pathways, these agents have yet to reach the market. The results from preclinical studies targeting therapeutic angiogenesis, neural regeneration, and anti-fibrosis are promising.
Recent Posts
Starting Testosterone Next Week. What Should I Expect?
Starting testosterone next week. What should I expect?
Nelson, I know you wrote the book "Testosterone: A Man's Guide". I was diagnosed with low testosterone...
Flawed Testosterone Studies Fuel Concerns and Lawsuits
A study published at the end of 2013 and a previous one from the Veterans Administration Hospital System (see below post) show what happens...
Nelson’s Tips on Nutrition, Exercise and Supplements
Here are some tips and suggestions :
Video: https://www.excelmale.com/content/15-...-Nelson-Vergel
Diet:
https://www.excelmale.com/showthread....Healthy-Eating
Exercise:
https://www.excelmale.com/showthread....-Exercise-Tips
Exercise web sites: https://www.exrx.net/Lists/Directory.html and https://www.myfit.ca/
Supplements:
Zinc/Copper: One, twice a day with food (this supports healthy testosterone and...
Antioxidants for the Treatment of Male Infertility: An Overview
Almost 15% of all couples trying to conceive are affected by infertility, and in almost half of these cases male infertility is the sole...
Low Testosterone Blood Level: How Low is Too Low?
VIDEO TRANSCRIPT:
Hormones change as we age. As you can tell, these are different hormones: estrogen, thyroid, progesterone, insulin, testosterone, cortisol, growth hormone, and this...