This HDL lowering effect is seen at higher testosterone doses.
Relationship of plasma HDL-Cholesterol to testosterone, estradiol, and sex-hormone-binding globulin levels in men and women
James Semmens et al.
Metabolism
Volume 32, Issue 5, May 1983, Pages 428–432
AbstractThe significance of sex hormone levels in determining variation in high-density lipoprotein cholesterol (HDL-C) concentrations was studied in healthy Seventh Day Adventists (vegetarians) and Mormons. These groups were selected to avoid the confounding effects of alcohol consumption and cigarette smoking on HDL-C concentrations. Multivariate analysis showed that testosterone has a strong negative association with HDL-C in men (t = 3.99, P < 0.001) and women (t = 2.04, P < 0.05) when controlled for other variables including the concentration of sex-hormone-binding globulin (SHBG). Sex-hormone-binding globulin showed an independent positive association with HDL-C in men (P < 0.001). We postulate that the sex hormones affect HDL-C levels by regulating the activities of two important enzymes involved in the production and catabolism of HDL, namely, lipoprotein lipase and hepatic endothelial lipase. Other factors contributing independently to variation in HDL-C levels in this study were, in men, age and triglyceride, and in women, apoprotein-HDL, triglyceride, systolic blood pressure, heart rate, body mass index, and triceps skinfold thickness. Plasma estradiol concentrations were not significantly associated in either sex.
Recent Posts
Penile Implants- Interview with Dr. Robert Cornell in Houston
Q & A with Robert J. Cornell, M.D. – Prosthetic Urology and Men’s Health Specialist
Robert J. Cornell, MD specializes in the treatment of genitourinary...
ED Drugs Troches and Capsules- Recommendations
Compounded PDE-5 Inhibitor Compounded Formulations (Empower Pharmacy) by Dosage Form:
I. Buccal Troche
Definition: Troches are small lozenges that dissolve between the cheek and gum over...
What You Should Know About the Main Side Effect of Testosterone
What You Should Know About the Main Side Effect of Testosterone
Testosterone replacement therapy (TRT) is one of the most effective ways to combat low...
Should You Be Injecting Testosterone Under the Skin?
Endocr Rev, Vol. 34 (03_MeetingAbstracts): MON-594
Evaluation of the efficacy of subcutaneous administration of testosterone in female to male transexuals and hypogonadal males
FDA-approved indications for...
Sex Hormone Synthesis, Regulation, and Function
The hypothalamus-pituitary-gonadal (HPG) axis
Sex hormone synthesis is controlled by the pulsatile release of hypothalamic gonadotropin-releasing hormone (GnRH)
At the pituitary gland, GnRH stimulates the release...