Anabolic/Androgenic Hormone Prescribing Indications

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Nandrolone Decanoate

Presentation: Injectable (IM-Depot) 100mg/mL; 200mg/mL X 10mL

Common dose range: 25mg qw- 400mg qw (or q month)

Active-life: 7-10 days post injection

Treatment and Indication:

Nandrolone was FDA approved in 1983 for treatment of Osteoporosis; anemia; and to treat some forms of neoplasia including breast cancer.

Nandrolone is indicated for the treatment of anemia associated with chronic and acute renal failure.

Nandrolone is indicated for Cachexia, most commonly in the form of; 1) HIV/AIDS wasting syndrome; Wasting caused by Tuberculosis;

Catabolic wasting commonly seen in wounded veterans; Superior mesenteric artery syndrome; Cancer Cachexia.

++Nandrolone is used to induce an increase in nitrogen retention and feed-efficiency for patients suffering metabolic acidosis.

++Nandrolone is used to treat musculoskeletal injuries and soft tissue trauma. Nandrolone is also prescribed to improve joint pain/injury. In addition Nandrolone is used to shorten recovery time post-surgery. This use is still controversial under the law.

++ Nandrolone is used for the treatment of muscle loss due to M.S and other neurological disease.

++ Off Label use

Nandrolone References for Review

· Therapeutic effects of nandrolone and testosterone in adult male HIV patients with AIDS wasting syndrome (AWS): a randomized, double-blind, placebo-controlled trial. Sardar P, Jha A, Roy D, Majumdar U, Guha P, Roy S, Banerjee R, Banerjee AK, Bandyopadhyay D. HIV Clin Trials. 2010 Jul-Aug;11(4):220-9.

· Beneficial effects of nandrolone decanoate in wasting associated with HIV. Saha B, Rajadhyaksha GC, Ray SK.J Indian Med Assoc. 2009 May;107(5):295-9.

· Nandrolone decanoate for men with osteoporosis. Hamdy RC, Moore SW, Whalen KE, Landy C. Am J Ther. 1998 Mar;5(2):89-95.

· Effects of nandrolone decanoate on bone mass in established osteoporosis. Passeri M, Pedrazzoni M, Pioli G, Butturini L, Ruys AH, Cortenraad MG. Maturitas. 1993 Nov;17(3):211-9.

· Anabolic steroids after total knee arthroplasty. A double blinded prospective pilot study. Hohmann E, Tetsworth K, Hohmann S, Bryant AL. J Orthop Surg Res. 2010 Dec 15;5:93.

· Nandrolone decanoate and load increase remodeling and strength in human supraspinatus bioartificial tendons. Triantafillopoulos IK, Banes AJ, Bowman KF Jr, Maloney M, Garrett WE Jr, Karas SG. Am J Sports Med. 2004 Jun;32(4):934-43. PMID:15150040[PubMed – indexed for MEDLINE]

.The treatment of multiple sclerosis with anabolic steroids.
Mall G, Heibrunn A, Paarmann HF, Jünemann HJ, Rheingans WR. Med Klin. 1968 Dec 20;63(51):2075-7. German. No abstract available. PMID:5730447[PubMed – indexed for MEDLINE]

http://savehivwastingmeds.blogspot.c…important.html

Both Oxandrolone and Nandrolone are effectively used in patients suffering pain and weakness caused by Fibromyalgia or Lupus.

Oxandrolone

Presentation: Capsule; Tablet; Sublingual Troche

Common dose range: PO: 2.5mg-40mg daily

Active life: 9h-12h

Treatment and Indication:

Oxandrolone is indicated as an adjunctive therapy tp promote weight-gain after weightloss following extensive surgery, chronic infections; or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or maintain normal weight.

Oxandrolone is indicated to offset the protein catabolism associated with prolonged administration o corticosteroids.

++ Oxandrolone is also used to offset severe protein catabolism which occurs with wasting syndrome associated with HIV/AIDS, Cancer, prolonged physical stress (combat); and sometimes unknown causes

Oxandrolone is indicated for the relief of bone pain frequently accompanying osteoporosis.

Oxandrolone is indicated for weight-gain in HIV/AIDs patients suffering from weight-loss

Oxandrolone is indicated for wound healing, most commonly for the treatment of burns. ( In a randomized, double-blind study, patients with 40% total body surface area burns were selected to receive standard burn care plus oxandrolone, or without oxandrolone. Those treated with oxandrolone showed improved body composition, preserved muscle mass and reduced hospital stay time.)

++ Off label use

Oxandrolone References for Review

· Earthman CP, Reid PM, Harper IT, Ravussin E, Howell WH (2002). “Body cell mass repletion and improved quality of life in HIV-infected individuals receiving oxandrolone”. JPEN J Parenter Enteral Nutr 26 (6): 357–65. doi:10.1177/0148607102026006357. PMID 12405647. http://pen.sagepub.com/cgi/pmidlooku…&pmid=12405647.

· Hart DW, Wolf SE, Ramzy PI, et al. (April 2001). “Anabolic effects of oxandrolone after severe burn”. Ann. Surg. 233 (4): 556–64. doi:10.1097/00000658-200104000-00012. PMC 1421286. PMID 11303139. http://meta.wkhealth.com/pt/pt-core/…ue=4&spage=556.

· Przkora R, Herndon DN, Suman OE (January 2007). “The effects of oxandrolone and exercise on muscle mass and function in children with severe burns”. Pediatrics 119 (1): e109–16. doi:10.1542/peds.2006-1548. PMC 2367234. PMID 17130281.

· Demling RH, DeSanti L (December 2003). “Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid”. Burns 29 (8): 793–7. doi:10.1016/j.burns.2003.08.003. PMID 14636753. http://linkinghub.elsevier.com/retri…05417903002316.

· Long-term oxandrolone treatment increases muscle protein net deposition via improving amino acid utilization in pediatric patients 6 months after burn injury. Tuvdendorj D, Chinkes DL, Zhang XJ, Suman OE, Aarsland A, Ferrando A, Kulp GA, Jeschke MG, Wolfe RR, Herndon DN. Surgery. 2011 May;149(5):645-53. Epub 2011 Feb 18.

· An update on promising agents for the treatment of cancer cachexia. Madeddu C, Mantovani G. Curr Opin Support Palliat Care. 2009 Dec;3(4):258-62. Review.

· The anabolic androgenic steroid oxandrolone in the treatment of wasting and catabolic disorders: review of efficacy and safety. Orr R, Fiatarone Singh M. Drugs. 2004;64(7):725-50. Review.

Stanozolol

Presentation: Tablet/Capsule

Common dose range: 2.5mg-20mg PO daily

Active life: ~8h

Treatment and Indications;

Stanozolol is indicated prophylactically to decrease the frequency and severity of attacks of hereditary angioedema. Given the serious potential adverse reactions, patients should be placed on the lowest possible effective dose.

++ Stanozolol is used in patients suffering from extreme wasting and rapid weight-loss (HIV/AIDS; Cancer Cachexia where anabolism is required within a short period of time in order to preserve the life of the patient. Other therapies, such as oxandrolone or nandrolone, have a delayed response due to longer half-life and or mechanism of action. In these extreme wasting cases, stanozolol serves as a more aggressive treatment.

Anabolic steroids and HIV

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